PI4KIIIbeta-IN-10 is a potent inhibitor of Pi4Kiiβ with an IC50 of 3.6 nM. It also showed weak inhibition of PI3KCγ, PI3Kα, and Pi4Kiiα, and inhibition of PI4K2α, PI4K2β, and PI3Kβ was less than 20% at concentrations up to 20 µM.

 

Brand: BCM

 

Target: PI3K; PI4K

 

Signaling Pathways: PI3K/Akt/mTOR signaling

 

pKa: 9.06±0.10(Predicted)

 

Solubility: Soluble in DMSO; soluble in Ethanol. Insoluble in Water.

 

Isomeric SMILES: CC1=C(SC(=N1)NC(=O)C(C)(C)C)C2=CC(=C(C=C2)OC)S(=O)(=O)NC3=CC=C(C=C3)O  

 

InChIKey: PLUYFBRIGUAKBR-UHFFFAOYSA-N  

 

InChI: InChI=1S/C22H25N3O5S2/c1-13-19(31-21(23-13)24-20(27)22(2,3)4)14-6-11-17(30-5)18(12-14)32(28,29)25-15-7-9-16(26)10-8-15/h6-12,25-26H,1-5H3,(H,23,24,27)

 

Attribute
[Chem Name]	N-[5-[3-[(4-hydroxyphenyl)sulfamoyl]-4-methoxyphenyl]-4-methyl-1,3-thiazol-2-yl]-2,2-dimethylpropanamide
[Synonym]	PI4KIIIbeta-IN-10;
[CAS No.]	1881233-39-1
[MDL No.]	MFCD30187514
[Formula]	C22H25N3O5S2
[Molecular]	475.58
[Form]	Solid Powder
[Storage]	Keep in dark place. Inert atmosphere. Room temperature

Goods Tag