MMRi62 is an iron death inducer targeting MDM2-MDM4 with a Kd value of 1.39 μM. It exhibits pro-apoptotic activity independent of P53 on pancreatic ductal adenocarcinoma cells (PDAC) and induces autophagy.

 

Brand: BCM

 

Target: Ferroptosis

 

Signaling Pathways: Apoptosis; Cell Cycle/Checkpoint

 

Solubility: Soluble in DMSO; soluble in Ethanol. Insoluble in Water.

 

Isomeric SMILES: C1=CC=NC(=C1)NC(C2=C(C(=CC=C2)Cl)Cl)C3=C(C4=C(C=CC=N4)C=C3)O  

 

InChIKey: FMUBUUSODRAEMS-UHFFFAOYSA-N  

 

InChI: InChI=1S/C21H15Cl2N3O/c22-16-7-3-6-14(18(16)23)20(26-17-8-1-2-11-24-17)15-10-9-13-5-4-12-25-19(13)21(15)27/h1-12,20,27H,(H,24,26) 

 

Attribute
[Chem Name]	7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol
[Synonym]	MMRi62
[CAS No.]	352693-80-2
[MDL No.]	MFCD01647927
[Formula]	C21H15Cl2N3O
[Molecular]	396.2693
[Form]	Solid Powder
[Storage]	4°C, protect from light

Goods Tag