BC-1215 is an inhibitor of F-box protein 3 (Fbxo3, a ubiquitin E3 ligase component) with an IC50 value of 0.9 μg/mL and an LC50 value of 87 μg/ml for IL-1β release. BC-1215 inhibits the Fbxo3-TRAF activation pathway by destabilizing TRAF1-6.

 

Brand: BCM

 

Target: Others; Ligand for E3 Ligase

 

Signaling Pathways: Others; PROTAC

 

In Vivo: A small molecule inhibitor BC-1215 argeting Fbxo3 was sufficient to lessen severity of cytokine-driven inflammation in several murine disease models.

 

Boiling Point: 589.9±50.0 °C(Predicted)

 

pKa: 9.05±0.20(Predicted)

 

Solubility: Soluble in DMSO; soluble in Ethanol. Insoluble in Water.

 

GHS: GHS07

 

Isomeric SMILES: C1=CC=NC(=C1)C2=CC=C(C=C2)CNCCNCC3=CC=C(C=C3)C4=CC=CC=N4  

 

InChIKey: IXEPQJQQSLMESJ-UHFFFAOYSA-N  

 

InChI: InChI=1S/C26H26N4/c1-3-15-29-25(5-1)23-11-7-21(8-12-23)19-27-17-18-28-20-22-9-13-24(14-10-22)26-6-2-4-16-30-26/h1-16,27-28H,17-20H2

 

Attribute
[Chem Name]	N,N'-bis[(4-pyridin-2-ylphenyl)methyl]ethane-1,2-diamine
[Synonym]	BC-1215
[CAS No.]	1507370-20-8
[MDL No.]	MFCD28118991
[Formula]	C26H26N4
[Molecular]	394.51
[Form]	White to beige solid
[Storage]	Keep in dark place. Sealed in dry, 2-8°C

Goods Tag