Itacnosertib (TP-0184) is a small molecule inhibitor of the BMP-1 receptor ALK2 (also known as ACVR1). Itacnosertib reduces ferrimodulin induction and elevated serum iron levels in turpentine and ACD lung cancer mouse models.

 

Brand: BCM

 

Boiling Point: 701.3±70.0 °C(Predicted)

 

pKa: 7.76±0.42(Predicted)

 

Solubility: Soluble in DMSO; soluble in Ethanol. Insoluble in Water.

 

Isomeric SMILES: CN1CCN(CC1)C2=C(C=C(C=C2)NC3=NC=CC(=N3)NC4=C(N=CC=C4)C5=CC=CC=N5)OC  

 

InChIKey: XSQKEVGTZSBVBR-UHFFFAOYSA-N  

 

InChI: InChI=1S/C26H28N8O/c1-33-14-16-34(17-15-33)22-9-8-19(18-23(22)35-2)30-26-29-13-10-24(32-26)31-21-7-5-12-28-25(21)20-6-3-4-11-27-20/h3-13,18H,14-17H2,1-2H3,(H2,29,30,31,32) 

 

Attribute
[Chem Name]	2-N-[3-methoxy-4-(4-methylpiperazin-1-yl)phenyl]-4-N-(2-pyridin-2-ylpyridin-3-yl)pyrimidine-2,4-diamine
[Synonym]	Itacnosertib; TP-0184
[CAS No.]	1628870-27-8
[MDL No.]	MFCD34578237
[Formula]	C26H28N8O
[Molecular]	468.55
[Form]	Solid Powder
[Storage]	Sealed in dry. Stored at -20°C.

Goods Tag