PBIT is a specific inhibitor of Jumonji AT-rich Interactive Domain 1 (JARID1) enzyme. It inhibits JARID1B (KDM5B/PLU1), JARID1A, and JARID1C with IC50 of 3 μM, 6 μM, and 4.9 μM, respectively. It inhibits the proliferation of breast cancer cell lines expressing high levels of JARIDB1.

 

Brand: BCM

 

Target: Histone Demethylase; Histone Methyltransferase

 

In Vitro: PBIT, which inhibits JARID1B with an IC50 of about 3 μm in vitro.?Consistent with this, PBIT treatment inhibited removal of H3K4me3 by JARID1B in cells.?Furthermore, this compound inhibited proliferation of cells expressing higher levels of JARID1B.

 

Melting Point: 136.7-137.1 °C(Solv: benzene (71-43-2); hexane (110-54-3))

 

Boiling Point: 418.2±38.0 °C(Predicted)

 

pKa: -0.03±0.20(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Water; Insoluble in Ethanol.

 

GHS: GHS07

 

Isomeric SMILES: CC1=CC=C(C=C1)N2C(=O)C3=CC=CC=C3S2  

 

InChIKey: KRXMYBAZKJBJAB-UHFFFAOYSA-N  

 

InChI: InChI=1S/C14H11NOS/c1-10-6-8-11(9-7-10)15-14(16)12-4-2-3-5-13(12)17-15/h2-9H,1H3

 

Attribute
[Chem Name]	2-(4-methylphenyl)-1,2-benzothiazol-3-one
[Synonym]	PBIT
[CAS No.]	2514-30-9
[EINECS]	604-604-1
[MDL No.]	MFCD05856231
[Formula]	C14H11NOS
[Molecular]	241.31
[Form]	White to beige powder
[Storage]	Sealed in dry. Room Temperature

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