Elacestrant (RAD1901) Dihydrochloride is a selective estrogen receptor degradation (SERD) with IC50 for ERα and ERβ of 48 nM and 870 nM, respectively.

 

Brand: BCM

 

Target: Estrogen/progestogen Receptor

 

Signaling Pathways: Endocrinology/Hormones

 

In Vivo: In MCF-7 xenograft models, Elacestrant-treated animals survived longer than those treated with either control or ICI 182780. RAD1901 preserves ovariectomy-induced bone loss and prevents the uterotropic effects of E2. Elacestrant produces a robust and profound inhibition of tumor growth in MCF-7 xenograft models

 

Solubility: Soluble in DMSO; Soluble in Water; Soluble in Ethanol.

 

Isomeric SMILES: CCNCCC1=CC=C(C=C1)CN(CC)C2=C(C=CC(=C2)OC)[C@@H]3CCC4=C(C3)C=CC(=C4)O.Cl.Cl  

 

InChIKey: XGFHYCAZOCBCRQ-FBHGDYMESA-N  

 

InChI: InChI=1S/C30H38N2O2.2ClH/c1-4-31-17-16-22-6-8-23(9-7-22)21-32(5-2)30-20-28(34-3)14-15-29(30)26-11-10-25-19-27(33)13-12-24(25)18-26;;/h6-9,12-15,19-20,26,31,33H,4-5,10-11,16-18,21H2,1-3H3;2*1H/t26-;;/m1../s1

 

Attribute
[Chem Name]	(6R)-6-[2-[ethyl-[[4-[2-(ethylamino)ethyl]phenyl]methyl]amino]-4-methoxyphenyl]-5,6,7,8-tetrahydronaphthalen-2-ol;dihydrochloride
[Synonym]	Elacestrant Dihydrochloride; RAD1901
[CAS No.]	1349723-93-8
[EINECS]	215-871-3
[MDL No.]	MFCD30532694
[Formula]	C30H40Cl2N2O2
[Molecular]	531.5568
[Form]	Solid Powder
[Storage]	Inert atmosphere. Store in freezer, under -20°C

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