INDY, a benzothiazole derivative, is a potent ATP competitive inhibitor of Dyrk1A and Dyrk1B with an IC50 value of 0.24 μM and a Ki value of 0.18 μM. INDY reduces the self-renewal capacity of normal and tumorigenic cells in primary glioblastoma (GBM) cell lines and neuroprogenitors.

 

Brand: BCM

 

Target: DYRK

 

Signaling Pathways: Cell Cycle/Checkpoint; Tyrosine Kinase/Adaptors

 

In Vitro: INDY effectively rescues the repressed NFAT signaling induced by Dyrk1A overexpression. In COS7 cells transfected with either EGFP-Dyrk1A or EGFP-tau, INDY mildly inhibits tau-phosphorylation at the dose of 3 μM, and inhibits nearly completely at the dose of 30 μM.

 

Boiling Point: 409.2±45.0 °C(Predicted)

 

pKa: 9.67±0.20(Predicted)

 

Solubility: Soluble in DMSO; Soluble in Ethanol. Insoluble in Water.

 

Isomeric SMILES: CCN\1C2=C(C=CC(=C2)O)S/C1=C\C(=O)C  

 

InChIKey: GCSZJMUFYOAHFY-SDQBBNPISA-N  

 

InChI: InChI=1S/C12H13NO2S/c1-3-13-10-7-9(15)4-5-11(10)16-12(13)6-8(2)14/h4-7,15H,3H2,1-2H3/b12-6-

 

Attribute
[Chem Name]	(1Z)-1-(3-ethyl-5-hydroxy-1,3-benzothiazol-2-ylidene)propan-2-one
[Synonym]	INDY
[CAS No.]	1169755-45-6
[MDL No.]	MFCD28100814
[Formula]	C12H13NO2S
[Molecular]	235.3
[Form]	White to beige powder
[Storage]	Sealed in dry. Stored at -20°C.

Goods Tag