Zidesamtinib (NVL-520) is a potent brain-penetrating ROS1 tyrosine kinase inhibitor with an IC50 of 0.7 nM against wild-type ROS1. It can be used in cancer research as a potential antitumor agent.

 

Brand: BCM

 

Boiling Point: 685.7±65.0 °C(Predicted)

 

pKa: 7.43±0.40(Predicted)

 

Solubility: Soluble in DMSO; Soluble in Ethanol. Insoluble in Water.

 

Isomeric SMILES: CCN1C2=C(CC3=NN(N=C3C4=C(C=C(C=C4)F)[C@H](OC5=C(N=CC2=C5)N)C)C)C=N1  

 

InChIKey: DTWUUAFTYSMNQX-GFCCVEGCSA-N  

 

InChI: InChI=1S/C22H22FN7O/c1-4-30-21-13(11-26-30)7-18-20(28-29(3)27-18)16-6-5-15(23)9-17(16)12(2)31-19-8-14(21)10-25-22(19)24/h5-6,8-12H,4,7H2,1-3H3,(H2,24,25)/t12-/m1/s1

 

Attribute
[Chem Name]	(19R)-3-ethyl-16-fluoro-10,19-dimethyl-20-oxa-3,4,9,10,11,23-hexazapentacyclo[19.3.1.02,6.08,12.013,18]pentacosa-1(25),2(6),4,8,11,13(18),14,16,21,23-decaen-22-amine
[Synonym]	Zidesamtinib; NVL-520; NVL520
[CAS No.]	2739829-00-4
[Formula]	C22H22FN7O
[Molecular]	419.46
[Form]	Solid Powder
[Storage]	Sealed in dry. Avoid heat and light. Stored at -20°C.

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