TRC051384 is an inducer of heat shock protein 70 (HSP70) and a potent anti-inflammatory agent.

 

Brand: BCM

 

Target: HSP

 

Signaling Pathways: Cytoskeletal Signaling; Metabolism

 

In Vitro: TRC051384 induces HSP70B mRNA by several hundred folds in both HeLa and rat primary mixed neurons in a dose-dependently manner. Treatment with TRC051384 results in a significant dose-dependent increase in HSF1 transcriptional activity and recovery of luciferase activity. TRC051384 results in 60% inhibition at 6.25 μM and 90% inhibition at 12.5 μM of LPS-induced TNF-α expression in differentiated THP-1 cell line

 

Boiling Point: 685.7±55.0 °C(Predicted)

 

pKa: 13.47±0.46(Predicted)

 

Solubility: Soluble in DMSO; Soluble in Ethanol. Insoluble in Water.

 

Isomeric SMILES: C1COCCN1CCNC(=O)NC2=CC=C(C=C2)C(=O)/C=C/C3=NC(=CC=C3)N4CCOCC4  

 

InChIKey: SQTSPANZQDCPLB-CMDGGOBGSA-N  

 

InChI: InChI=1S/C25H31N5O4/c31-23(9-8-21-2-1-3-24(27-21)30-14-18-34-19-15-30)20-4-6-22(7-5-20)28-25(32)26-10-11-29-12-16-33-17-13-29/h1-9H,10-19H2,(H2,26,28,32)/b9-8+

 

Attribute
[Chem Name]	1-(2-morpholin-4-ylethyl)-3-[4-[(E)-3-(6-morpholin-4-ylpyridin-2-yl)prop-2-enoyl]phenyl]urea
[Synonym]	TRC051384
[CAS No.]	867164-40-7
[MDL No.]	MFCD28133369
[Formula]	C25H31N5O4
[Molecular]	465.54
[Form]	Yellow solid
[Storage]	Sealed in dry. Away from light. Store in freezer, under -20°C

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