JG-98 is an allosteric inhibitor of Hsp70, which binds tightly to the conserved deep pockets of members of the Hsp70 family. JG-98 induces classic apoptotic features, including morphological changes consistent with programmed cell death and positive annexin staining. JG-98 has anticancer activity.

 

Brand: BCM

 

Target: Apoptosis; HSP

 

Signaling Pathways: Apoptosis; Cytoskeletal Signaling; Metabolism

 

In Vitro: JG-98 had a potency of 0.4 ± 0.03 μM against MDA-MB-231 cells and an EC50 value of 0.7 ± 0.2 μM for MCF7 cells. In MDA-MB-231 cells, the treatment of JG-98 activated apoptotic mediators (caspase-3 and PARP). Treatment of both MDA-MB-231 and MCF7 cells with JG-98 strongly affected autophagic flux. JG-98 has antiproliferative activity (EC50 values between 0.3 and 4 μmol/L) across cancer cell lines from multiple origins. JG-98 destabilized FoxM1 and relieved suppression of downstream effectors, including p21 and p27.

 

Solubility: Soluble in DMSO. Insoluble in Water; Insoluble in Ethanol.

 

GHS: GHS07

 

Isomeric SMILES: CCN1/C(=C/C2=[N+](C=CS2)CC3=CC=CC=C3)/S/C(=C/4\N(C5=C(S4)C=C(C=C5)Cl)C)/C1=O.[Cl-]  

 

InChIKey: AUPPGWXGMILTRB-HDPAMLMOSA-M  

 

InChI: InChI=1S/C24H21ClN3OS3.ClH/c1-3-28-21(14-20-27(11-12-30-20)15-16-7-5-4-6-8-16)32-22(23(28)29)24-26(2)18-10-9-17(25)13-19(18)31-24;/h4-14H,3,15H2,1-2H3;1H/q+1;/p-1/b24-22+; 

 

Attribute
[Chem Name]	(2Z,5E)-2-[(3-benzyl-1,3-thiazol-3-ium-2-yl)methylidene]-5-(6-chloro-3-methyl-1,3-benzothiazol-2-ylidene)-3-ethyl-1,3-thiazolidin-4-one;chloride
[Synonym]	JG98; JG-98
[CAS No.]	1456551-16-8
[MDL No.]	MFCD32067914
[Formula]	C24H21Cl2N3OS3
[Molecular]	534.53
[Form]	Solid Powder
[Storage]	Inert atmosphere, 2-8°C

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