JSH-23 is an inhibitor of NF-κB transcriptional activity with IC50 of 7.1 μM in RAW 264.7 cell line.

 

Brand: BCM

 

Target: NF-κB

Signaling Pathways: NF-κB

 

In Vitro: In diabetic rats,JSH-23 (3 mg/kg) can reduce neuroinflammation and improve antioxidant defense, significantly reverse nerve conduction, and ultimately improve nerve blood flow deficiency.

 

In Vivo: In RAW 264.7 cells,JSH-23<100 μM showed no obvious toxic effect and inhibited the apoptotic chromatin concentration induced by lipopolysaccharide. In mouse cerebellar primary cells,JSH-23 inhibited LPS-induced NF-κB p65 nuclear transport without affecting IκBα degradation.

 

Melting Point: 104.4-105.0℃

 

Boiling Point: 418.7±40.0 °C(Predicted)

 

pKa: 5.99±0.11(Predicted)

 

Solubility: Soluble in DMSO; Soluble in Ethanol. Insoluble in Water.

 

GHS: GHS05, GHS07, GHS09

 

Isomeric SMILES: CC1=CC(=C(C=C1)NCCCC2=CC=CC=C2)N  

 

InChIKey: YMFNPBSZFWXMAD-UHFFFAOYSA-N  

 

InChI: InChI=1S/C16H20N2/c1-13-9-10-16(15(17)12-13)18-11-5-8-14-6-3-2-4-7-14/h2-4,6-7,9-10,12,18H,5,8,11,17H2,1H3

 

Attribute
[Chem Name]	4-methyl-1-N-(3-phenylpropyl)benzene-1,2-diamine
[Synonym]	JSH-23
[CAS No.]	749886-87-1
[MDL No.]	MFCD09753595
[Formula]	C16H20N2
[Molecular]	240.34
[Form]	Off-white solid
[Storage]	Keep in dark place. Sealed in dry. Store in freezer, under -20°C

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