SKI-178 is a potent sphingosine kinase-1 (SphK1) and SphK2 inhibitor with an IC50 range of about 500 nM-1 μM in acute myeloid leukemia (AML) cell lines.

 

Brand: BCM

 

Target: Apoptosis; S1P Receptor

 

Signaling Pathways: Apoptosis; GPCR/G Protein

 

In Vitro: SKI-178 is a multi-targeted agent that functions both as an inhibitor of the SphKs as well as a disruptor of the microtubule network.?SKI-178 induced apoptosis arises from a synergistic interaction of these two activities.?SKI-178 is safe and effective in mouse models of AML, supporting its further development as a multi-targeted anti-cancer therapeutic agent

 

pKa: 9.25±0.46(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Water; Insoluble in Ethanol.

 

Isomeric SMILES: CC(=NNC(=O)C1=CC(=NN1)C2=CC=C(C=C2)OC)C3=CC(=C(C=C3)OC)OC  

 

InChIKey: GMFUWEBOUKIKRP-UHFFFAOYSA-N  

 

InChI: InChI=1S/C21H22N4O4/c1-13(15-7-10-19(28-3)20(11-15)29-4)22-25-21(26)18-12-17(23-24-18)14-5-8-16(27-2)9-6-14/h5-12H,1-4H3,(H,23,24)(H,25,26)

 

Attribute
[Chem Name]	N-[1-(3,4-dimethoxyphenyl)ethylideneamino]-3-(4-methoxyphenyl)-1H-pyrazole-5-carboxamide
[Synonym]	SKI-178; SKI 178
[CAS No.]	1259484-97-3
[MDL No.]	MFCD01913555
[Formula]	C21H22N4O4
[Molecular]	394.42
[Form]	A crystalline solid
[Storage]	Keep in dark place. Inert atmosphere. Store in freezer, under -20°C

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