Dclk1-in-1 is a selective IN vivo compatible chemical probe in the doublecortin like kinase 1 (DCLK1) domain that binds to DCLK1 and DCLK2 with corresponding IC50 of 9.5 nM and 31 nM, respectively. IN the determination of kinase activity, the IC50 of DCLK1-in-1 inhibiting DCLK1 and DCLK2 kinases was 57.2 nM and 103 nM, respectively.

 

Brand: BCM

 

Target: Others

 

Signaling Pathways: Others

 

Boiling Point: 692.4±65.0 °C(Predicted)

 

pKa: 7.75±0.42(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Water; Insoluble in Ethnaol. 

 

Isomeric SMILES: CN1CCN(CC1)C2=CC(=C(C=C2)NC3=NC=C4C(=N3)N(C5=CC=CC=C5C(=O)N4CC(F)(F)F)C)OC  

 

InChIKey: OQFCHSFVWSLDAO-UHFFFAOYSA-N  

 

InChI: InChI=1S/C26H28F3N7O2/c1-33-10-12-35(13-11-33)17-8-9-19(22(14-17)38-3)31-25-30-15-21-23(32-25)34(2)20-7-5-4-6-18(20)24(37)36(21)16-26(27,28)29/h4-9,14-15H,10-13,16H2,1-3H3,(H,30,31,32)

 

Attribute
[Chem Name]	2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-11-methyl-5-(2,2,2-trifluoroethyl)pyrimido[4,5-b][1,4]benzodiazepin-6-one
[Synonym]	DCLK1-IN-1
[CAS No.]	2222635-15-4
[MDL No.]	MFCD32671365
[Formula]	C26H28F3N7O2
[Molecular]	527.54
[Form]	Solid Powder
[Storage]	Sealed in dry, 2-8°C

Goods Tag