NVP-BVU972 is a potent, selective Met (c-Met) inhibitor with an IC50 of 14 nM.

 

Brand: BCM

 

Target: c-Met/HGFR

 

Signaling Pathways: Tyrosine Kinase/Adaptors

 

In Vivo: NVP-BVU972 effectively inhibited the growth of MET gene diffused cell lines GTL-16,MKN-45, and EBC-1 with IC50 of 66,82, and 32 nM, respectively. Nfp-bvu972 effectively inhibits MET kinase, while RON inhibition on other kinases (including the most closely related kinases) is very low, with IC50>1000 nM. Nfp-bvu972 inhibited constitutive MET phosphorylation in GTL-16 cells and HGF-stimulated MET phosphorylation in A549 cells with IC50 values of 7.3 and 22 nM, respectively. Nfp-bvu972 acts on BaF3 cells expressing wild-type TPR-MET, reducing TPR-MET phosphorylation in a dose-dependent manner.

 

pKa: 4.92±0.10(Predicted)

 

Solubility: Soluble in DMSO; Soluble in Ethanol. Insoluble in Water.

 

GHS: GHS07

 

Isomeric SMILES: CN1C=C(C=N1)C2=NN3C(=NC=C3CC4=CC5=C(C=C4)N=CC=C5)C=C2

 

InChIKey: RNCNPRCUHHDYPC-UHFFFAOYSA-N

 

InChI: InChI=1S/C20H16N6/c1-25-13-16(11-23-25)19-6-7-20-22-12-17(26(20)24-19)10-14-4-5-18-15(9-14)3-2-8-21-18/h2-9,11-13H,10H2,1H3

 

Attribute
[Chem Name]	6-[[6-(1-methylpyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]methyl]quinoline
[Synonym]	NVP-BVU972
[CAS No.]	1185763-69-2
[EINECS]	200-258-5
[MDL No.]	MFCD22420820
[Formula]	C20H16N6
[Molecular]	340.38
[Form]	Solid Powder
[Storage]	Keep in dark place. Inert atmosphere. Room temperature

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