CCT020312 is a selective PERK (EIF2AK3) activator with an EC50 of 5.1 μM. CCT020312 can be used to selectively activate EIF2A-mediated translation control.

 

Brand: BCM

 

Target: PERK

 

Signaling Pathways: Apoptosis

 

In Vitro: In HT29 cells, CCT020312 reduces the P-S608-pRB signal with a linear response between 1.8 and 6.1 μM in a concentration-dependent manner. CCT020312(10 μM) decreases G1/S cyclins D1, D2, E, and A, reduces the CDK catalytic subunit CDK2 and increased the level of the p27KIP1

 

pKa: 9.43±0.70(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Water; Insoluble in Ethanol.

 

Isomeric SMILES: CCN(CC)CCC(=O)N1C(CC(=N1)C2=C(C3=C(C=CC(=C3)Br)NC2=O)C4=CC=CC=C4)C5=CC=C(C=C5)Br  

 

InChIKey: OAXDKXMGESZLKV-UHFFFAOYSA-N  

 

InChI: InChI=1S/C31H30Br2N4O2/c1-3-36(4-2)17-16-28(38)37-27(20-10-12-22(32)13-11-20)19-26(35-37)30-29(21-8-6-5-7-9-21)24-18-23(33)14-15-25(24)34-31(30)39/h5-15,18,27H,3-4,16-17,19H2,1-2H3,(H,34,39) 

 

Attribute
[Chem Name]	6-bromo-3-[3-(4-bromophenyl)-2-[3-(diethylamino)propanoyl]-3,4-dihydropyrazol-5-yl]-4-phenyl-1H-quinolin-2-one
[Synonym]	CCT020312
[CAS No.]	324759-76-4
[Formula]	C31H30Br2N4O2
[Molecular]	650.4
[Form]	Solid Powder
[Storage]	Sealed in dry. Stored at -20°C.

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