Poseltinib (HM71224, LY3337641) has a high selective inhibition effect on Bruton's tyrosine kinase (BTK), with IC50 of 1.95 nM. The selectivity for other BMX, TEC and TXK was 0.3, 2.3 and 2.4 times, respectively.

 

Brand: BCM

 

Target: BTK

 

pKa: 12.85±0.70(Predicted)

 

Solubility: Soluble in DMSO; Soluble in Ethanol. Insoluble in Water.

 

Isomeric SMILES: CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC4=C(C(=N3)OC5=CC=CC(=C5)NC(=O)C=C)OC=C4  

 

InChIKey: LZMJNVRJMFMYQS-UHFFFAOYSA-N  

 

InChI: InChI=1S/C26H26N6O3/c1-3-23(33)27-19-5-4-6-21(17-19)35-25-24-22(11-16-34-24)29-26(30-25)28-18-7-9-20(10-8-18)32-14-12-31(2)13-15-32/h3-11,16-17H,1,12-15H2,2H3,(H,27,33)(H,28,29,30)

 

Attribute
[Chem Name]	N-[3-[2-[4-(4-methylpiperazin-1-yl)anilino]furo[3,2-d]pyrimidin-4-yl]oxyphenyl]prop-2-enamide
[Synonym]	Poseltinib; HM71224; LY3337641
[CAS No.]	1353552-97-2
[MDL No.]	MFCD31729279
[Formula]	C26H26N6O3
[Molecular]	470.52
[Form]	Solid Powder
[Storage]	Sealed in dry, 2-8°C

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