Ikk-16 is a selective IκB kinase (IKK) inhibitor that acts on IKK-2, IKK complex, and IKK-1 with IC50 of 40 nM, 70 nM, and 200 nM, respectively, in cell-free trials. IKK-16 also inhibited the intracellular phosphorylation of LRRK2 Ser935 and the kinase activity of LRRK2 in vitro with an IC50 value of 50 nM.

 

Brand: BCM

 

Target: IκB/IKK; LRRK2

 

Signaling Pathways: Autophagy; NF-κB

 

In Vitro: IKK-16 inhibits TNFα-stimulated expression of the adhesion molecules E-selectin, ICAM-1, and VCAM-1 in HUVEC cells. Although IKK-16 shows activity in the IFNγ-induced expression of β2 microglobulin or HLA-DR, its potency in these assays is 4- to 10-fold weaker.

 

In Vivo: IKK-16 is orally active in rats and mice, inhibits LPS induced TNF-α release in vivo, and also inhibits neutrophil exosmosis in thioglia-induced peritonitis.

 

Solubility: Soluble in DMSO. Insoluble in Water; Insoluble in Ethanol.

 

GHS: GHS07

 

Isomeric SMILES: C1CCN(C1)C2CCN(CC2)C(=O)C3=CC=C(C=C3)NC4=NC=CC(=N4)C5=CC6=CC=CC=C6S5  

 

InChIKey: BWZJBXAPRCVCKQ-UHFFFAOYSA-N  

 

InChI: InChI=1S/C28H29N5OS/c34-27(33-17-12-23(13-18-33)32-15-3-4-16-32)20-7-9-22(10-8-20)30-28-29-14-11-24(31-28)26-19-21-5-1-2-6-25(21)35-26/h1-2,5-11,14,19,23H,3-4,12-13,15-18H2,(H,29,30,31) 

 

Attribute
[Chem Name]	[4-[[4-(1-benzothiophen-2-yl)pyrimidin-2-yl]amino]phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone
[Synonym]	IKK-16; IKK Inhibitor VII
[CAS No.]	873225-46-8
[MDL No.]	MFCD23704180
[Formula]	C28H29N5OS
[Molecular]	483.63
[Form]	Solid Powder
[Storage]	Keep in dark place,Sealed in dry. Store in freezer, under -20°C

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