AZD5069 is a novel CXCR2 antagonist, which can inhibit the binding of CXCL8 and CXCR2 with pIC50 value of 8.8. When CXCL8 was inhibited from binding to CXCR1, pIC50 was 6.5.

 

Brand: BCM

 

Target: CXCR

 

Signaling Pathways: Autophagy; GPCR/G Protein; Immunology/Inflammation

 

In Vitro: AZD5069 inhibited neutrophil chemotaxis, with a pA2 of approximately 9.6, and adhesion molecule expression, with a pA2 of 6.9, in response to CXCL1.

 

Melting Point: 149-152°C

 

Boiling Point: 680.5±65.0 °C(Predicted)

 

pKa: 4.56±0.20(Predicted)

 

Solubility: Soluble in DMSO; Soluble in Ethanol. Insoluble in Water.

 

GHS: GHS08

 

Isomeric SMILES: C[C@H]([C@H](CO)O)OC1=NC(=NC(=C1)NS(=O)(=O)N2CCC2)SCC3=C(C(=CC=C3)F)F  

 

InChIKey: QZECRCLSIGFCIO-RISCZKNCSA-N  

 

InChI: InChI=1S/C18H22F2N4O5S2/c1-11(14(26)9-25)29-16-8-15(23-31(27,28)24-6-3-7-24)21-18(22-16)30-10-12-4-2-5-13(19)17(12)20/h2,4-5,8,11,14,25-26H,3,6-7,9-10H2,1H3,(H,21,22,23)/t11-,14+/m1/s1 

 

Attribute
[Chem Name]	N-[2-[(2,3-difluorophenyl)methylsulfanyl]-6-[(2R,3S)-3,4-dihydroxybutan-2-yl]oxypyrimidin-4-yl]azetidine-1-sulfonamide
[Synonym]	AZD5069; AZD-5069
[CAS No.]	878385-84-3
[MDL No.]	MFCD31631376
[Formula]	C18H22F2N4O5S2
[Molecular]	476.52
[Form]	White to Off-White Solid
[Storage]	Keep in dark place. Inert atmosphere. Store in freezer, under -20°C

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