Bardoxolone (CDDO, RTA 401) acts by releasing Nrf2 from KEAP1, is an activator of Nrf2, and can induce apoptosis in cancer cells.

 

Brand: BCM

 

Target: Others; Nrf2

 

Signaling Pathways: Immunology/Inflammation; Others

 

In Vitro: Bardoxolone methyl is a novel synthetic triterpenoid and antioxidant inflammation modulator that potently induces Nrf2 and inhibits NF-κB and Janus-activated kinase/STAT signaling. Bardoxolone methyl has been shown to induce differentiation, inhibit proliferation, and induce apoptosis in cancer cell lines.

 

Melting Point: 180-182 °C

 

Boiling Point: 632.9±55.0 °C(Predicted)

 

pKa: 4.52±0.70(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Water; Insoluble in Ethanol.

 

GHS: GHS07

 

Isomeric SMILES: C[C@@]12CC[C@]3(CCC(C[C@H]3[C@H]1C(=O)C=C4[C@]2(CC[C@@H]5[C@@]4(C=C(C(=O)C5(C)C)C#N)C)C)(C)C)C(=O)O  

 

InChIKey: TXGZJQLMVSIZEI-UQMAOPSPSA-N  

 

InChI: InChI=1S/C31H41NO4/c1-26(2)10-12-31(25(35)36)13-11-30(7)23(19(31)16-26)20(33)14-22-28(5)15-18(17-32)24(34)27(3,4)21(28)8-9-29(22,30)6/h14-15,19,21,23H,8-13,16H2,1-7H3,(H,35,36)/t19-,21-,23-,28-,29+,30+,31-/m0/s1

 

Attribute
[Chem Name]	(4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,3,4,5,6,7,8,8a,14a,14b-decahydropicene-4a-carboxylic acid
[Synonym]	Bardoxolone; https://www.selleck.cn/products/bardoxolone.html#:~:text=%E5%88%AB%E5%90%8D%3A-,CDDO,-%2C%20RTA%20401%20%E4%B8%AD%E6%96%87
[CAS No.]	218600-44-3
[MDL No.]	MFCD07772296
[Formula]	C31H41NO4
[Molecular]	491.66
[Form]	Solid Powder
[Storage]	Sealed in dry. Store in freezer, under -20°C

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