RU.521 (RU320521) is a potent and selective inhibitor of active cyclic GMP-AMP synthase (cGAS), which inhibits cGAS-mediated signaling with an IC50 value of 700 nM. RU.521 bound to the cGAS/dsDNA complex with a Kd value of 36.2 nM.

 

Brand: BCM

 

Target: DNA; cGAS

 

Signaling Pathways: DNA Damage/DNA Repair; Immunology/Inflammation

 

In Vivo: Treatment of primary BMDMs with RU.521 or its analogs reduced IFNB1 expression in mice, indicating their effectiveness in suppressing intrinsic DNA-dependent, constitutively-activated type I interferon expression in cells deficient of a cytoplasmic DNA exonuclease.

 

Boiling Point: 658.2±65.0 °C(Predicted)

 

pKa: 6.17±0.30(Predicted)

 

Solubility: Soluble in DMSO; Soluble in Ethanol. Insoluble in Water.

 

GHS: GHS07

 

Isomeric SMILES: CC1=C(C(=O)N(N1)C2=NC3=C(N2)C=CC(=C3Cl)Cl)C4C5=CC=CC=C5C(=O)O4  

 

InChIKey: IAWZUQAOMURCLV-UHFFFAOYSA-N  

 

InChI: InChI=1S/C19H12Cl2N4O3/c1-8-13(16-9-4-2-3-5-10(9)18(27)28-16)17(26)25(24-8)19-22-12-7-6-11(20)14(21)15(12)23-19/h2-7,16,24H,1H3,(H,22,23)

 

Attribute
[Chem Name]	2-(4,5-dichloro-1H-benzimidazol-2-yl)-5-methyl-4-(3-oxo-1H-2-benzofuran-1-yl)-1H-pyrazol-3-one
[Synonym]	RU.521; RU320521
[CAS No.]	2262452-06-0
[MDL No.]	MFCD32173679
[Formula]	C19H12Cl2N4O3
[Molecular]	415.23
[Form]	Off-white to pale pink solid
[Storage]	Keep in dark place. Sealed in dry. Store in freezer, under -20°C

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