Brefeldin A (BFA) acts on HCT 116 cells to inhibit lactone antibiotics and ATPase and on protein transport (protein transport) with an IC50 of 0.2 μM to induce cancer cell differentiation and apoptosis. It also improves the efficiency of homologous recombination repair and is an enhancer of CRISPR-mediated HDR. Brefeldin A is also an inhibitor of autophagy and mitophagy.

 

Brand: BCM

 

Target: ATPase; Mitophagy; Antibiotic; Autophagy; HSV; CRISPR/Cas9

 

Signaling Pathways: Autophagy; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology

 

In Vitro: In HF4.9 and HF28RA cells, Brefeldin A (25 ng/mL) completely inhibited cell growth. In HF1A3 cells,Brefeldin A (75 ng/mL) completely inhibited cell growth.

 

Melting Point: 200-205 °C

Specific Rotation: 93 º (C=2 IN MEOH)

 

Boiling Point: 492.7±45.0 °C(Predicted)

 

Flash Point: 87 °C

 

pKa: 12.92±0.60(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Water; Insoluble in Ethanol.

 

GHS: GHS06

 

Isomeric SMILES: C[C@H]1CCC/C=C/[C@@H]2C[C@@H](C[C@H]2[C@@H](/C=C/C(=O)O1)O)O  

 

InChIKey: KQNZDYYTLMIZCT-KQPMLPITSA-N  

InChI: InChI=1S/C16H24O4/c1-11-5-3-2-4-6-12-9-13(17)10-14(12)15(18)7-8-16(19)20-11/h4,6-8,11-15,17-18H,2-3,5,9-10H2,1H3/b6-4+,8-7+/t11-,12+,13-,14+,15+/m0/s1

 

Attribute
[Chem Name]	(1R,2R,3E,7S,11E,13S,15S)-2,15-dihydroxy-7-methyl-6-oxabicyclo[11.3.0]hexadeca-3,11-dien-5-one
[Synonym]	Brefeldin A; BFA; Cyanein; Decumbin
[CAS No.]	20350-15-6
[EINECS]	606-528-3
[MDL No.]	MFCD12913297
[Formula]	C16H24O4
[Molecular]	280.36
[Form]	White to off-white powder
[Storage]	Sealed in dry. Store in freezer, under -20°C

Goods Tag