CFTRinh-172 (CFTR inhibitor 172) is a potential dip-independent, selective CFTR inhibitor with Ki of 300 nM and no effect on MDR1, ATP-sensitive potassium channels or a range of transporters.

 

Brand: BCM

 

Target: CFTR; Autophagy

 

Signaling Pathways: Autophagy; Membrane transporter/Ion channel

 

In Vitro: 6 h 20 μg CFTRinh-172 completely abolished V. cholera-induced secretion of intestinal fluid without affecting V. cholera-induced growth in vivo.

 

In Vivo: As a selective CFTR channel inhibitor, CFTRinh-172 was able to completely eliminate Cl − current in rabbit lacrimal gland acinar and duct cells. CFTRinh-172 inhibited CFTR-mediated iodide transport in a time - and dose-dependent manner and effectively inhibited CFTR activation by a variety of agonists or activators. CFTRinh-172 induced ROS production, mitochondrial failure and activation of the NF-κB signaling pathway independent of CFTR inhibition.

 

Melting Point: 181-183 °C

 

Boiling Point: 555.7±60.0 °C(Predicted)

 

pKa: 3.88±0.10(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Water; Insoluble in Ethanol.

 

GHS: GHS07, GHS09

 

Isomeric SMILES: C1=CC(=CC(=C1)N2C(=O)/C(=C/C3=CC=C(C=C3)C(=O)O)/SC2=S)C(F)(F)F  

 

InChIKey: JIMHYXZZCWVCMI-ZSOIEALJSA-N  

 

InChI: InChI=1S/C18H10F3NO3S2/c19-18(20,21)12-2-1-3-13(9-12)22-15(23)14(27-17(22)26)8-10-4-6-11(7-5-10)16(24)25/h1-9H,(H,24,25)/b14-8-

 

Attribute
[Chem Name]	4-[(Z)-[4-oxo-2-sulfanylidene-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene]methyl]benzoic acid
[Synonym]	CFTRinh-172; CFTR inhibitor 172
[CAS No.]	307510-92-5
[MDL No.]	MFCD06411408
[Formula]	C18H10F3NO3S2
[Molecular]	409.4
[Form]	Yellow solid
[Storage]	Sealed in dry, 2-8°C

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