Dimesna (BNP-7787) is a uroprotective agent that can be used in combination with cancer chemotherapy drugs to reduce urotoxicity.

 

Brand: BCM

 

In Vitro: Dimesna can reduce cyclophosphamide in a dose-dependent manner in rat bladder cancer.

 

In Vivo: Dimesna regulates paclitaxel-induced hyperpolymerization of MTP, while mesna, the in vivo metabolite of Dimesna, prevents cisplatin-induced inactivation of MTP. Renal organic anion transporters OAT1 (KM=636 μM),OAT3 (KM=390 μM) and OAT4 (KM=590 μM) specifically bound Dimesna.

 

Melting Point: 273 °C (decomp)

 

Stability: Hygroscopic

 

Solubility: Soluble in DMSO; Soluble in Water. Insoluble in Ethanol.

 

GHS: GHS07

 

Isomeric SMILES: C(CS(=O)(=O)[O-])SSCCS(=O)(=O)[O-].[Na+].[Na+]  

 

InChIKey: KQYGMURBTJPBPQ-UHFFFAOYSA-L  

 

InChI: InChI=1S/C4H10O6S4.2Na/c5-13(6,7)3-1-11-12-2-4-14(8,9)10;;/h1-4H2,(H,5,6,7)(H,8,9,10);;/q;2*+1/p-2

 

Attribute
[Chem Name]	disodium;2-(2-sulfonatoethyldisulfanyl)ethanesulfonate
[Synonym]	Dimesna; BNP-7787
[CAS No.]	16208-51-8
[EINECS]	240-337-2
[MDL No.]	MFCD00868218
[Formula]	C4H8Na2O6S4
[Molecular]	326.34
[Form]	White to Off-White Solid
[Storage]	Inert atmosphere, 2-8°C

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