Loganin (Loganoside) is an iridoid glycoside first isolated from the seeds of Strychnos nux-vomica, a member of the Loganiaceae family. It is a non-competitive inhibitor of BACE1 with IC50 of 47.97 μM an also inhibits AChE and BChE with IC50 values of 3.95 μM and 33.02 μM, respectively.

 

Brand: BCM

 

Target: Apoptosis; NF-κB; BACE; AChR; AChE

 

Signaling Pathways: Apoptosis; Neuroscience; NF-κB

 

Melting Point: 222°C

 

Specific Rotation: D20 -82.1° (water)

 

Boiling Point: 608.8±55.0 °C(Predicted)

 

pKa: 12.80±0.70(Predicted)

 

Solubility: Soluble in DMSO.

 

GHS: GHS07

 

Isomeric SMILES: C[C@H]1[C@H](C[C@H]2[C@@H]1[C@@H](OC=C2C(=O)OC)O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O)O  

 

InChIKey: AMBQHHVBBHTQBF-UOUCRYGSSA-N  

 

InChI: InChI=1S/C17H26O10/c1-6-9(19)3-7-8(15(23)24-2)5-25-16(11(6)7)27-17-14(22)13(21)12(20)10(4-18)26-17/h5-7,9-14,16-22H,3-4H2,1-2H3/t6-,7+,9-,10+,11+,12+,13-,14+,16-,17-/m0/s1

 

Attribute
[Chem Name]	methyl (1S,4aS,6S,7R,7aS)-6-hydroxy-7-methyl-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylate
[Synonym]	Loganin; Loganoside
[CAS No.]	18524-94-2
[EINECS]	242-398-0
[MDL No.]	MFCD00075645
[Formula]	C17H26O10
[Molecular]	390.38
[Form]	White to off-white powder
[Storage]	Sealed in dry. Room Temperature

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