FIIN-3 is an irreversible FGFR inhibitor with IC50 of 13.1, 21, 31.4 and 35.3 nM against FGFR1, FGFR2, FGFR3 and FGFR4, respectively.

 

Brand: BCM

 

Target: EGFR; FGFR

 

Signaling Pathways: Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors

 

Boiling Point: 909.4±65.0 °C(Predicted)

 

pKa: 10.78±0.70(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Water; Insoluble in Ethanol.

 

GHS: GHS07

 

Isomeric SMILES: CN1CCN(CC1)C2=CC=C(C=C2)NC3=CC(=NC=N3)N(CC4=CC=C(C=C4)NC(=O)C=C)C(=O)NC5=C(C(=CC(=C5Cl)OC)OC)Cl  

 

InChIKey: SFLKJNSBBVSPFE-UHFFFAOYSA-N  

 

InChI: InChI=1S/C34H36Cl2N8O4/c1-5-30(45)40-24-8-6-22(7-9-24)20-44(34(46)41-33-31(35)26(47-3)18-27(48-4)32(33)36)29-19-28(37-21-38-29)39-23-10-12-25(13-11-23)43-16-14-42(2)15-17-43/h5-13,18-19,21H,1,14-17,20H2,2-4H3,(H,40,45)(H,41,46)(H,37,38,39)

 

Attribute
[Chem Name]	N-[4-[[(2,6-dichloro-3,5-dimethoxyphenyl)carbamoyl-[6-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]amino]methyl]phenyl]prop-2-enamide
[Synonym]	FIIN-3
[CAS No.]	1637735-84-2
[MDL No.]	MFCD28386554
[Formula]	C34H36Cl2N8O4
[Molecular]	691.61
[Form]	A crystalline solid
[Storage]	Store at -20°C

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