Merbarone(NSC 336628) is a catalytic inhibitor of topoisomerase II with an IC50 of 120 μM and has anti-proliferative activity against human cancer cells. Merbarone acts primarily by blocking topoisomerase II-mediated DNA cleavage.

 

Brand: BCM

 

pKa: -2.16±0.20(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Water; Insoluble in Ethanol.

 

Isomeric SMILES: C1=CC=C(C=C1)NC(=O)C2C(=O)NC(=S)NC2=O  

 

InChIKey: JARCFMKMOFFIGZ-UHFFFAOYSA-N  

 

InChI: InChI=1S/C11H9N3O3S/c15-8(12-6-4-2-1-3-5-6)7-9(16)13-11(18)14-10(7)17/h1-5,7H,(H,12,15)(H2,13,14,16,17,18)

 

Attribute
[Chem Name]	4,6-dioxo-N-phenyl-2-sulfanylidene-1,3-diazinane-5-carboxamide
[Synonym]	Merbarone; NSC 336628
[CAS No.]	Merbarone
[MDL No.]	MFCD00866337
[Formula]	C11H9N3O3S
[Molecular]	263.27
[Form]	Solid Powder
[Storage]	Stored at -20°C

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