PF-04957325 is a potent and selective PDE8 inhibitor with IC50 values of 0.7 nM and 0.3 nM for PDE8A and PDE8B, respectively. PF-04957325 greatly enhanced steroidogenesis in wild-type adrenal cells.

 

Brand: BCM

 

Target: PDE8A:0.7 nM

 

In Vitro: PF-04957325 is a selective PDE8 inhibitor and inhibits breast cancer cell migration. PF-04957325 shows a reported IC50 of 0.7 nM against PDE8A, 0.2 nM against PDE8B, and > 1.5 μM against all other PDE isoforms.

 

pKa: 4.51±0.10(Predicted)

 

Solubility: Soluble in DMSO; Soluble in Ethanol. Insoluble in Water.

 

Isomeric SMILES: C1CO[C@H](CN1CC2=NC=CS2)CN3C4=NC(=NC(=C4N=N3)N)C(F)(F)F  

 

InChIKey: VNLPYEMGHGDRRZ-MRVPVSSYSA-N  

 

InChI: InChI=1S/C14H15F3N8OS/c15-14(16,17)13-20-11(18)10-12(21-13)25(23-22-10)6-8-5-24(2-3-26-8)7-9-19-1-4-27-9/h1,4,8H,2-3,5-7H2,(H2,18,20,21)/t8-/m1/s1

 

Attribute
[Chem Name]	3-[[(2R)-4-(1,3-thiazol-2-ylmethyl)morpholin-2-yl]methyl]-5-(trifluoromethyl)triazolo[4,5-d]pyrimidin-7-amine
[Synonym]	PF-04957325
[CAS No.]	1305115-80-3
[Formula]	C14H15F3N8OS
[Molecular]	400.38
[Form]	Solid Powder
[Storage]	Stored at -20°C

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