Deltarasin is a small molecule inhibitor that inhibits the KRAS-PDEδ interaction and binds to pure PDEδ with a Kd value of 38 nM.

 

Brand: BCM

 

Target: PDE; Ras

 

Signaling Pathways: GPCR/G Protein; MAPK; Metabolism

 

In Vitro: In liver cells, Deltarasin inhibits the interaction of RAS with PDEδ with KD of 41 nM. Inhibition of PDEδ-KRAS interaction by Deltarasin suppresses proliferation of human pancreatic ductal adenocarcinoma cells that are dependent on oncogenic KRAS.

 

Boiling Point: 824.3±75.0 °C(Predicted)

 

pKa: 10.35±0.10(Predicted)

 

Solubility: Soluble in DMSO; Soluble in Ethanol. Insoluble in Water.

 

GHS: GHS07

 

Isomeric SMILES: C1CNCCC1[C@@H](COC2=CC=C(C=C2)C3=NC4=CC=CC=C4N3CC5=CC=CC=C5)N6C7=CC=CC=C7N=C6C8=CC=CC=C8  

 

InChIKey: LTZKEDSUXKTTTC-KXQOOQHDSA-N  

 

InChI: InChI=1S/C40H37N5O/c1-3-11-29(12-4-1)27-44-36-17-9-7-15-34(36)42-39(44)32-19-21-33(22-20-32)46-28-38(30-23-25-41-26-24-30)45-37-18-10-8-16-35(37)43-40(45)31-13-5-2-6-14-31/h1-22,30,38,41H,23-28H2/t38-/m1/s1

 

Attribute
[Chem Name]	1-benzyl-2-[4-[(2S)-2-(2-phenylbenzimidazol-1-yl)-2-piperidin-4-ylethoxy]phenyl]benzimidazole
[Synonym]	Deltarasin;
[CAS No.]	1440898-61-2
[MDL No.]	MFCD26793865
[Formula]	C40H37N5O
[Molecular]	603.75
[Form]	White solid
[Storage]	Keep in dark place. Sealed in dry. Store in freezer, under -20°C

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