WIKI4 is a novel Tankyrase inhibitor with an IC50 of 15 nM on TNKS2 and also has an inhibitory effect on Wnt/ß-catenin signaling pathway.

 

Brand: BCM

 

Target: PARP; Wnt/beta-catenin

 

Signaling Pathways: Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Stem Cells

 

InVitro: WIKI4 inhibited Wnt/ ß-catenin signaling in all cell lines tested, including A375, DLD1 colorectal cancer, NALM6 B, U2OS osteosarcoma, and hESCs. WIKI4 increases the steady-state abundance of Wnt/ ß-catenin arrestins and AXIN1 by inhibiting end-anchor polymerase activity, thereby preventing ubiquitination and degradation of AXIN proteins.

 

Boiling Point: 783.1±70.0 °C(Predicted)

 

pKa: 1.70±0.10(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Water; Insoluble in Ethanol.

 

GHS: GHS07

 

Isomeric SMILES: COC1=CC=C(C=C1)N2C(=NN=C2SCCCN3C(=O)C4=CC=CC5=C4C(=CC=C5)C3=O)C6=CC=NC=C6  

 

InChIKey: RNUXIZKXJOGYQP-UHFFFAOYSA-N  

 

InChI: InChI=1S/C29H23N5O3S/c1-37-22-11-9-21(10-12-22)34-26(20-13-15-30-16-14-20)31-32-29(34)38-18-4-17-33-27(35)23-7-2-5-19-6-3-8-24(25(19)23)28(33)36/h2-3,5-16H,4,17-18H2,1H3

 

Attribute
[Chem Name]	2-[3-[[4-(4-methoxyphenyl)-5-pyridin-4-yl-1,2,4-triazol-3-yl]sulfanyl]propyl]benzo[de]isoquinoline-1,3-dione
[Synonym]	WIKI4
[CAS No.]	838818-26-1
[MDL No.]	MFCD05885187
[Formula]	C29H23N5O3S
[Molecular]	521.59
[Form]	white to beige powder
[Storage]	Keep in dark place. Inert atmosphere. Room temperature

Goods Tag