1400W (N-(3-(Aminomethyl)benzyl)acetamidine) is an inhibitor of iNOS that binds slowly, tightly and selectively.

 

Brand: BCM

 

Target: NOS; NO Synthase

 

Signaling Pathways: Immunology/Inflammation

 

In Vitro: 1400W is either an irreversible inhibitor or an extremely slowly reversible inhibitor of human iNOS. Inhibition of human iNOS by 1400W is time-dependent. 1400W is competitive with L-arginine. 1400W is not a substrate for iNOS.

 

Melting Point: 208 °C

 

Solubility: Soluble in DMSO; Soluble in Water; Soluble in Ethanol.

 

Isomeric SMILES: CC(=NCC1=CC=CC(=C1)CN)N.Cl.Cl  

 

InChIKey: WDJHSQZCZGPGAA-UHFFFAOYSA-N  

 

InChI: InChI=1S/C10H15N3.2ClH/c1-8(12)13-7-10-4-2-3-9(5-10)6-11;;/h2-5H,6-7,11H2,1H3,(H2,12,13);2*1H

 

Attribute
[Synonym]	1400W 2HCl
[CAS No.]	214358-33-5
[MDL No.]	MFCD03428622
[Formula]	C8H11NO
[Molecular]	137.17904
[Form]	White solid
[Storage]	Keep in dark place. Inert atmosphere. Store in freezer, under -20°C
[Chem Name]	N'-[[3-(aminomethyl)phenyl]methyl]ethanimidamide;dihydrochloride

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