L-Arginine HCl (L-Arg,(S)-(+) -arginine hydrochloride), a nitrogen donor for nitric oxide synthesis, is a potent vasodilator that is insufficient in sickle cell anemia.

 

Brand: BCM

 

Target: Amino Acids and Derivatives; Endogenous Metabolite; NO Synthase

 

Signaling Pathways: Immunology/Inflammation; Metabolism

 

In Vitro: Oral administration of L-Arginine (0.1 g/kg) for 5 days significantly reduced pulmonary artery systolic pressure in patients with sickle cell anemia. L-Arginine (4 mg/kg/min) treatment for 1 h reduced superoxide production and increased NO accumulation by cNOS in the limbs of rabbits after ischemia/reperfusion. In SV-129 mice, eNOS was upregulated by subcutaneous injection of L-Arginine (2 mg/kg).

 

Melting Point: 226-230 °C(lit.)

 

Boiling Point: 235℃[at 101 325 Pa]

 

Odor: Odorless

 

PH: 5.5-7.0 (25℃, 1M in H2O)

 

Solubility: Soluble in Water. Insoluble in DMSO; Insoluble in Ethanol.

 

GHS: GHS07

 

Isomeric SMILES: C(C[C@@H](C(=O)O)N)CN=C(N)N.Cl  

 

InChIKey: KWTQSFXGGICVPE-WCCKRBBISA-N  

 

InChI: InChI=1S/C6H14N4O2.ClH/c7-4(5(11)12)2-1-3-10-6(8)9;/h4H,1-3,7H2,(H,11,12)(H4,8,9,10);1H/t4-;/m0./s1

 

Attribute
[Chem Name]	(2S)-2-amino-5-(diaminomethylideneamino)pentanoic acid;hydrochloride
[Synonym]	L-Arginine HCl (L-Arg); (S)-(+)-Arginine hydrochloride
[CAS No.]	1119-34-2
[EINECS]	214-275-1
[MDL No.]	MFCD00064550
[Formula]	C6H15ClN4O2
[Molecular]	210.66
[Form]	White powder
[Storage]	Inert atmosphere. Room Temperature

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