2-DG (2-Deoxy-D-glucose), a glucose analogue, is a glycolytic inhibitor with antiviral activity. 2-Deoxy-D-glucose could induce apoptosis and inhibit the expression of Herpes Simplex Virus type-1 (HSV-1) receptor.

 

Brand: BCM

 

Target: Apoptosis; Hexokinase; HSV

 

Signaling Pathways: Apoptosis; Metabolism; Microbiology/Virology

 

In Vitro: 2-Deoxy-D-glucose(2-DG) activates AKT function through phosphatidylinositol 3-kinase (PI3K) and is independent of glycolysis or mTOR inhibition. 2-DG treatments disrupts the binding between insulin-like growth factor 1 (IGF-1) and IGF-binding protein 3 (IGFBP3) so that the free form of IGF-1 could be released from the IGF-1·IGFBP3 complex to activate IGF-1 receptor (IGF1R) signaling. 2-DG-induced activation of many survival pathways can be jointly attenuated through IGF1R inhibition. 2-DG also induces time- and dose-dependent ERK phosphorylation. 2-DG is readily transported into cells and is phosphorylated by hexokinase, but cannot be metabolized further and accumulates in the cell. This leads to ATP depletion and the induction of cell-death. 2DG significantly suppresses proliferation, causes apoptosis and reduces migration of murine endothelial cells, inhibiting formation of lamellipodia and filopodia and causing disorganization of F-actin filaments in murine endothelial cell.

 

Melting Point: 146-147 °C(lit.)

 

Specific Rotation: 45.5 º (c=2, H2O)

 

Boiling Point: 211.61°C (rough estimate)

 

Solubility: Soluble in DMSO; Soluble in Water; Soluble in Ethanol.

 

GHS: GHS07

 

Isomeric SMILES: C(C=O)[C@H]([C@@H]([C@@H](CO)O)O)O  

 

InChIKey: VRYALKFFQXWPIH-PBXRRBTRSA-N  

 

InChI: InChI=1S/C6H12O5/c7-2-1-4(9)6(11)5(10)3-8/h2,4-6,8-11H,1,3H2/t4-,5-,6+/m1/s1

 

Attribute
[Chem Name]	(3R,4S,5R)-3,4,5,6-tetrahydroxyhexanal
[Synonym]	2-DG; 2-Deoxy-D-glucose; 2-deoxyglucose; NSC 15193; 2-Deoxy-D-arabino-hexose; D-Arabino-2-deoxyhexose
[CAS No.]	154-17-6
[EINECS]	205-823-0
[MDL No.]	MFCD00151328
[Formula]	C6H12O5
[Molecular]	164.16
[Form]	White Solid
[Storage]	Inert atmosphere. Store in freezer, under -20°C

Goods Tag

Nodakenetin

$195