Ripretinib is an orally active inhibitor of Kit (c-Kit) and PDGFR-alpha, The IC50 for WT Kit (c-Kit), V654A Kit (c-Kit), T670I Kit (c-Kit), D816H Kit (c-Kit), and D816V Kit (c-Kit) was 4 nM, 8 nM, 18 nM, 5 nM, and 14, respectively nM.

 

Brand: BCM

 

Target: Apoptosis; VEGFR; FLT; PDGFR; c-Kit

 

Signaling Pathways: Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors

 

Boiling Point: 568.6±50.0 °C(Predicted)

 

pKa: 12.15±0.70(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Water; Insoluble in Ethanol.

 

GHS: GHS07

 

Isomeric SMILES: CCN1C2=CC(=NC=C2C=C(C1=O)C3=CC(=C(C=C3Br)F)NC(=O)NC4=CC=CC=C4)NC  

 

InChIKey: CEFJVGZHQAGLHS-UHFFFAOYSA-N  

 

InChI: InChI=1S/C24H21BrFN5O2/c1-3-31-21-12-22(27-2)28-13-14(21)9-17(23(31)32)16-10-20(19(26)11-18(16)25)30-24(33)29-15-7-5-4-6-8-15/h4-13H,3H2,1-2H3,(H,27,28)(H2,29,30,33)

 

Attribute
[Chem Name]	1-[4-bromo-5-[1-ethyl-7-(methylamino)-2-oxo-1,6-naphthyridin-3-yl]-2-fluorophenyl]-3-phenylurea
[Synonym]	Ripretinib; DCC-2618
[CAS No.]	1442472-39-0
[MDL No.]	MFCD31657437
[Formula]	C24H21BrFN5O2
[Molecular]	510.36
[Form]	A solid
[Storage]	Keep in dark place. Sealed in dry, 2-8°C

Goods Tag