Pexidartinib, also know as PLX-3397, is a CSF1R inhibitor with IC50 of 20 nM in development by Plexxikon for the treatment of tenosynovial giant cell tumors. It is in a phase 3 clinical trial for Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCT-TS).

 

Brand: BCM

 

Solubility: Soluble in DMSO (up to at least 10 mg/ml). Insoluble in Water.

 

InChi Key: JGWRKYUXBBNENE-UHFFFAOYSA-N

 

Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.

 

Attribute
[CAS No.]	1029044-16-3
[Formula]	C20H15ClF3N5
[Molecular]	417.81
[Form]	White solid
[Storage]	-20°C
[MDL No.]	MFCD28900745
[Chem Name]	5-((5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)-N-((6-(trifluoromethyl)pyridin-3-yl)methyl)pyridin-2-amine
[Synonym]	PLX3397; PLX-3397; PLX 3397; CML-261; CML 261; CML261; FP-113; FP 113; FP113; Pexidartinib; Turalio

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