GDC-0994 is a potent, oral and selective ERK1/2 inhibitor with IC50 of 1.1 nM and 0.3 nM, respectively. Phase 1.

 

Brand: BCM

 

Boiling Point: 734.6±70.0 °C(Predicted)

 

Solubility: ≥44.1 mg/mL in DMSO; insoluble in H2O; ≥19.2 mg/mL in EtOH

 

Isomeric SMILES: CN1C(=CC=N1)NC2=NC=CC(=N2)C3=CC(=O)N(C=C3)[C@H](CO)C4=CC(=C(C=C4)Cl)F  

 

InChIKey: RZUOCXOYPYGSKL-GOSISDBHSA-N  

 

InChI: InChI=1S/C21H18ClFN6O2/c1-28-19(5-8-25-28)27-21-24-7-4-17(26-21)13-6-9-29(20(31)11-13)18(12-30)14-2-3-15(22)16(23)10-14/h2-11,18,30H,12H2,1H3,(H,24,26,27)/t18-/m1/s1

 

Attribute
[CAS No.]	1453848-26-4
[Formula]	C21H18ClFN6O2
[Molecular]	440.86
[Form]	Yellow powder
[Storage]	-20℃
[MDL No.]	MFCD28143918
[Chem Name]	1-[(1S)-1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl]-4-[2-[(2-methylpyrazol-3-yl)amino]pyrimidin-4-yl]pyridin-2-one
[Synonym]	GDC-0994

Goods Tag