Name：Trametinib (GSK1120212)

Catalog No.：
BCM002123

CAS No.：
871700-24-2

Formula：
C26H23FIN5O4

Molecular：
615.3947932

MDL No.：
MFCD18207185

Chem Name：
3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-5-hydroxy-6,8-dimethylpyrido[2,3-d]pyrimidine-2,4,7-trione

Synonym：
Trametinib; GSK1120212; JTP-74057

Storage：
Keep in dark place. Sealed in dry, 2-8°C

Form：
White to Off-White Solid

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SKU	Specification	Brand	Prices	Stock	Cart
BCM002123-250MG	250mg, Purity:98%	BCM	$20	2	Add Cart
BCM002123-1G	1g, Purity:98%	BCM	$50	2	Add Cart
BCM002123-5G	5g, Purity:98%	BCM	$165	2	Add Cart

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Trametinib (GSK1120212, JTP-74057) is a highly specific and potent MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM in cell-free tests, and has no inhibitory activity against c-Raf, B-Raf, and ERK1/2. Trametinib can activate autophagy and induce apoptosis.

Brand: BCM

Boiling Point: 518.2±60.0°C at 760 mmHg

pKa: 4.50±1.00(Predicted)

GHS: GHS07

Solubility: Soluble in DMSO (warmed with 50ºC water bath). Insoluble in Water; insoluble in Ethanol.

Isomeric SMILES: CC1=C(C2=C(N(C1=O)C)N(C(=O)N(C2=O)C3CC3)C4=C(C=C(C=C4)I)F)O

InChIKey: MHHFXMZMCYWCJQ-UHFFFAOYSA-N

InChI: InChI=1S/C18H15FIN3O4/c1-8-14(24)13-15(21(2)16(8)25)23(12-6-3-9(20)7-11(12)19)18(27)22(17(13)26)10-4-5-10/h3,6-7,10,24H,4-5H2,1-2H3

Attribute

[CAS No.] 871700-24-2

[Formula] C26H23FIN5O4

[Molecular] 615.3947932

[MDL No.] MFCD18207185

[Chem Name] 3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-5-hydroxy-6,8-dimethylpyrido[2,3-d]pyrimidine-2,4,7-trione

[Synonym] Trametinib; GSK1120212; JTP-74057

[Storage] Keep in dark place. Sealed in dry, 2-8°C

[Form] White to Off-White Solid

Attribute
[CAS No.]	871700-24-2
[Formula]	C26H23FIN5O4
[Molecular]	615.3947932
[MDL No.]	MFCD18207185
[Chem Name]	3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-5-hydroxy-6,8-dimethylpyrido[2,3-d]pyrimidine-2,4,7-trione
[Synonym]	Trametinib; GSK1120212; JTP-74057
[Storage]	Keep in dark place. Sealed in dry, 2-8°C
[Form]	White to Off-White Solid