Name：Cabozantinib

Catalog No.：
BCM002126

CAS No.：
849217-68-1

Formula：
C28H24FN3O5

Molecular：
502

Chem Name：
1,1-Cyclopropanedicarboxamide,N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-

Synonym：
Cabozantinib; XL184; BMS-907351

Storage：
-20°C

EINECS：
692-846-8

MDL No.：
MFCD20926324

Form：
White powder

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SKU	Specification	Brand	Prices	Stock	Cart
BCM002126-500MG	500mg, Purity:98%	BCM	$95	2	Add Cart
BCM002126-1G	1g, Purity:98%	BCM	$149	2	Add Cart
BCM002126-10G	10g, Purity:98%	BCM	$800	2	Add Cart
BCM002126-50G	50g, Purity:98%	BCM	$1989	2	Add Cart

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Product Description

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Cabozantinib (XL184, BMS-907351) is a potent inhibitor of VEGFR2 with an IC50 of 0.035 nM in cell-free trials and is capable of inhibiting c-Met, Ret, Kit, Flt-1/3/4, Tie2 and AXL, IC50 were 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respectively. Cabozantinib induces Puma-dependent apoptosis in colon cancer cells via the AKT/GSK-3β/NF-κB signaling pathway.

Brand: BCM

Melting Point: 212-215°C

pKa: 13.86±0.70(Predicted)

Solubility: Soluble in DMSO. Insoluble in Water and Ethanol.

Attribute

[CAS No.] 849217-68-1

[Formula] C28H24FN3O5

[Molecular] 502

[Chem Name] 1,1-Cyclopropanedicarboxamide,N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-

[Synonym] Cabozantinib; XL184; BMS-907351

[Storage] -20°C

[EINECS] 692-846-8

[MDL No.] MFCD20926324

[Form] White powder

Attribute
[CAS No.]	849217-68-1
[Formula]	C28H24FN3O5
[Molecular]	502
[Chem Name]	1,1-Cyclopropanedicarboxamide,N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-
[Synonym]	Cabozantinib; XL184; BMS-907351
[Storage]	-20°C
[EINECS]	692-846-8
[MDL No.]	MFCD20926324
[Form]	White powder