Olaparib (AZD2281, KU0059436) is a selective PARP1/2 inhibitor with IC50 of 5 nM/1 nM. Its effect on PARP1/2 is 300 times higher than that of Tankyrase-1. Olaparib can significantly induce mitochondrial autophagy associated autophagy in BRCA mutated cells.

 

Brand: BCM

 

Target: Mitophagy; PARP; Autophagy

 

Signaling Pathways: Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair

 

pKa: 12.07±0.40(Predicted)

 

Solubility: Soluble in DMSO (up to 33 mg/ml) or in Ethanol (up to 1.7 mg/ml)

 

GHS: GHS05

 

Isomeric SMILES: C1CC1C(=O)N2CCN(CC2)C(=O)C3=C(C=CC(=C3)CC4=NNC(=O)C5=CC=CC=C54)F  

 

InChIKey: FDLYAMZZIXQODN-UHFFFAOYSA-N  

 

InChI: InChI=1S/C24H23FN4O3/c25-20-8-5-15(14-21-17-3-1-2-4-18(17)22(30)27-26-21)13-19(20)24(32)29-11-9-28(10-12-29)23(31)16-6-7-16/h1-5,8,13,16H,6-7,9-12,14H2,(H,27,30)

 

Attribute
[CAS No.]	763113-22-0
[Formula]	C24H23FN4O3
[Molecular]	434.469
[MDL No.]	MFCD13185161
[Chem Name]	4-(3-(4-(cyclopropanecarbonyl)piperazine-1-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one
[Synonym]	Olaparib
[Storage]	-20°C
[EINECS]	642-941-5
[Form]	Off-white solid

Goods Tag