PF-00562271, a benzene sulfonate of PF-562271, is a potent, ATP-competitive, reversible inhibitor of FAK with an IC50 of 1.5 nM. It is about 10 times less effective on Pyk2 than on FAK and more than 100 times more selective on other protein kinases (except some CDKs). Phase 1.

 

Solubility: Soluble in DMSO. Insoluble in Water.

 

Attribute
[Chem Name]	PF-562271 besylate
[Synonym]	RS0038s; Methanesulfonamide,N-[3-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]-2-pyridinyl]-N-methyl-,benzenesulfonate (1:1); PF-562,271; N-methyl-N-(3-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethylpyrimidin-4-ylamino]methyl}pyridin-2-yl)methanesulfonamide monobesylate; benzenesulfonic acid,N-methyl-N-[3-[[[2-[(2-oxo-1,3-dihydroindol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]methyl]pyridin-2-yl]methanesulfonamide;
[CAS No.]	939791-38-5
[Formula]	C27H26F3N7O6S2
[Molecular]	665.66
[Storage]	Under inert gas (nitrogen or Argon) at 2-8°C
[MDL No.]	MFCD14105612
[Form]	Solid
[Risk Codes]	GHS07

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