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Lovastatin (MK-803, Mevinolin,Mevacor) is an HMG-CoA reductase inhibitor with an IC50 of 3.4 nM in cell-free trials for cholesterol-lowering (lipid-lowering agents). Lovastatin triggers autophagy.
Brand: BCM
Melting Point: 175°C
Boiling Point: 559.2 °C at 760 mmHg
Specific Rotation: D25 +323° (c = 0.5 g in 100 ml acetonitrile)
pKa: 13.49±0.40(Predicted)
Solubility: Soluble in DMSO; soluble in Ethanol. Insoluble in Water.
Isomeric SMILES: CC[C@H](C)C(=O)O[C@H]1C[C@H](C=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@@H]3C[C@H](CC(=O)O3)O)C
InChIKey: PCZOHLXUXFIOCF-BXMDZJJMSA-N
InChI: InChI=1S/C24H36O5/c1-5-15(3)24(27)29-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-19-12-18(25)13-22(26)28-19/h6-7,10,14-16,18-21,23,25H,5,8-9,11-13H2,1-4H3/t14-,15-,16-,18+,19+,20-,21-,23-/m0/s1
Attribute [Formula] C24H36O5 [Molecular] 404.54000 [CAS No.] 75330-75-5 [Chem Name] [(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate [Form] White solid [Synonym] lovastatin; MK-803; Mevinolin; Mevacor [EINECS] 616-212-7 [MDL No.] MFCD00072164 [Storage] Keep in dark place. Inert atmosphere. Room temperature
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