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PD173074 is a potent FGFR1 inhibitor with an IC50 of about 25 nM in cell-free tests and also inhibits VEGFR2 with an IC50 of 100-200 nM. The selectivity of FGFR1 is about 1000 times higher than that of PDGFR and c-Src.
Brand: BCM
Melting Point: 82-85°C
pKa: 10.12±0.43(Predicted)
Solubility: Soluble in DMSO. Insoluble in Water.
Attribute [CAS No.] 219580-11-7 [Formula] C28H41N7O3 [Molecular] 523.682 [MDL No.] MFCD08705327 [Chem Name] 1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea [Synonym] PD-173074;PD173074;PD 173074 [Form] Yellow solid [Storage] 2-8 °C
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