PND-1186, also known as SR-2156 and VS-4718, is a potent FAK inhibitor with a 50% inhibitory concentration (IC50) of 1.5 nM in vitro. PND-1186 has an IC50 of ~100 nM in breast carcinoma cells. Notably, 1.0 µM PND-1186 (>5-fold above IC50) had limited effects on cell proliferation. However, under non-adherent conditions as spheroids and as colonies in soft agar, 0.1 µM PND-1186 blocked FAK and p130Cas tyrosine phosphorylation, promoted caspase-3 activation, and triggered cell apoptosis. PND-1186 inhibited 4T1 breast carcinoma subcutaneous tumor growth correlated with elevated tumor cell apoptosis and caspase 3 activation.

 

Brand: BCM

 

Boiling Point: 654.0±55.0 °C at 760 mmHg

 

Flashing Point: 349.3±31.5 °C

 

Solubility: Soluble in DMSO. Insoluble in Water. Insoluble in Ethanol.

 

InChi Key: IGUBBWJDMLCRIK-UHFFFAOYSA-N

 

Attribute
[CAS No.]	1061353-68-1
[Formula]	C25H26F3N5O3
[Molecular]	501.5008496
[Chem Name]	2-((2-((2-methoxy-4-morpholinophenyl)amino)-5-(trifluoromethyl)pyridin-4-yl)amino)-N-methylbenzamide.
[Storage]	Sealed in dry. Stored at -20°C
[Synonym]	PND1186; PND 1186; PND1186; SR 2516; SR2516; SR2516; VS4718; VS4718; VS 4718
[MDL No.]	MFCD28125506
[Form]	Off-white to grey solid powder

Goods Tag