Siremadlin (HDM201) is a novel, highly efficient and selective inhibitor of p53-Mdm2 interaction. The affinity constant of Mdm2 is in the picomol range, and the selectivity of Mdm2 is more than 1000 times that of Mdm4.

 

Brand: BCM

 

Target: E1/E2/E3 Enzyme

 

Signaling Pathways: Ubiquitination

 

In Vitro: Siremadlin inhibits both human and murine TP53- MDM2 interactions, with nanomolar cellular IC50 values, blocking TP53 degradation

 

Boiling Point: 736.5±70.0 °C(Predicted)

 

pKa: 1.33±0.29(Predicted)

 

Solubility: Soluble in DMSO; Soluble in Ethanol. Insoluble in Water.

 

GHS: GHS07

 

Isomeric SMILES: CC(C)N1C2=C(C(=O)N([C@H]2C3=CC=C(C=C3)Cl)C4=CC(=CN(C4=O)C)Cl)N=C1C5=CN=C(N=C5OC)OC  

 

InChIKey: AGBSXNCBIWWLHD-FQEVSTJZSA-N  

 

InChI: InChI=1S/C26H24Cl2N6O4/c1-13(2)33-21-19(30-22(33)17-11-29-26(38-5)31-23(17)37-4)25(36)34(18-10-16(28)12-32(3)24(18)35)20(21)14-6-8-15(27)9-7-14/h6-13,20H,1-5H3/t20-/m0/s1

 

Attribute
[CAS No.]	1448867-41-1
[Formula]	C26H24Cl2N6O4
[Molecular]	555.41256
[Chem Name]	(4S)-5-(5-chloro-1-methyl-2-oxopyridin-3-yl)-4-(4-chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-3-propan-2-yl-4H-pyrrolo[3,4-d]imidazol-6-one
[Synonym]	NVP-HDM201; HDM201
[Storage]	Sealed in dry, 2-8°C
[MDL No.]	MFCD30502893
[Form]	Solid Powder

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