PF-477736 (PF-736, PF-00477736) is A potent, selective, ATP-competitive Chk1 inhibitor with a Ki of 0.49 nM in cell-free trials, and also inhibits VEGFR2, Orora-A, FGFR3, Flt3, Fms (CSF1R), VEGFR2, FGFR3, and FMS. Ret and Yes. Action on Chk1 is about 100 times more selective than action on Chk2.

 

Brand: BCM

 

Target: c-Fms; VEGFR; FGFR; FLT; c-RET; Chk; CDK; Src; Aurora Kinase

 

Signaling Pathways: Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Tyrosine Kinase/Adaptors

 

pKa: 11.79±0.20(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Water; insoluble in Ethanol.

 

Isomeric SMILES: CN1C=C(C=N1)C2=C3C=NNC(=O)C4=C3C(=CC(=C4)NC(=O)[C@@H](C5CCCCC5)N)N2  

 

InChIKey: NDEXUOWTGYUVGA-LJQANCHMSA-N  

 

InChI: InChI=1S/C22H25N7O2/c1-29-11-13(9-25-29)20-16-10-24-28-21(30)15-7-14(8-17(27-20)18(15)16)26-22(31)19(23)12-5-3-2-4-6-12/h7-12,19,27H,2-6,23H2,1H3,(H,26,31)(H,28,30)/t19-/m1/s1

 

Attribute
[CAS No.]	952021-60-2
[Formula]	C22H25N7O2
[Molecular]	419.48
[Chem Name]	(2R)-2-amino-2-cyclohexyl-N-[2-(1-methylpyrazol-4-yl)-9-oxo-3,10,11-triazatricyclo[6.4.1.04,13]trideca-1,4,6,8(13),11-pentaen-6-yl]acetamide
[Synonym]	PF 477736; PF-736; PF-00477736
[Storage]	Keep in dark place. Sealed in dry, 2-8°C
[MDL No.]	MFCD16038847
[Form]	Yellow powder

Goods Tag