PD0166285 is a potent Wee1 and Chk1 inhibitor with IC50 values of 24 nM and 72 nM for Wee1 and Myt1, respectively. PD0166285 is also a novel inhibitor of G2 checkpoint. PD0166285 can induce apoptosis.

 

Brand: BCM

 

Target: Chk1:3.4 μM, Myt1:72 nM, Wee1:24 nM

Boiling Point:  665.3±65.0 °C(Predicted)

 

Solubility: Soluble in DMSO; soluble in Ethanol. Insoluble in Water.

 

pKa: 9.65±0.25(Predicted)

 

GHS: GHS07

 

Isomeric SMILES: CCN(CC)CCOC1=CC=C(C=C1)NC2=NC=C3C=C(C(=O)N(C3=N2)C)C4=C(C=CC=C4Cl)Cl  

 

InChIKey: IFPPYSWJNWHOLQ-UHFFFAOYSA-N  

 

InChI: InChI=1S/C26H27Cl2N5O2/c1-4-33(5-2)13-14-35-19-11-9-18(10-12-19)30-26-29-16-17-15-20(25(34)32(3)24(17)31-26)23-21(27)7-6-8-22(23)28/h6-12,15-16H,4-5,13-14H2,1-3H3,(H,29,30,31)

 

Attribute
[CAS No.]	185039-89-8
[Formula]	C26H27Cl2N5O2
[Molecular]	512.43
[Chem Name]	6-(2,6-dichlorophenyl)-2-[4-[2-(diethylamino)ethoxy]anilino]-8-methylpyrido[2,3-d]pyrimidin-7-one
[Synonym]	PD0166285; PD-0166285; PD 0166285; TCMDC-140940
[Storage]	Keep in dark place. Inert atmosphere, 2-8°C
[MDL No.]	MFCD00950060
[Form]	Solid

Goods Tag