NU6027 is a potent ATR/CDK inhibitor that inhibits CDK1/2, ATR, and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM, and 2.2 μM, respectively, and enters cells more easily than 6-aminopurine inhibitors.

 

Brand: BCM

 

Target: CDK1:2.5 μM(Ki), ATR:0.4 μM(Ki), DNA-PK:2.2 μM(Ki), CDK2:1.3 μM(Ki)

 

Signaling Pathways: Cell Cycle/Checkpoint; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling

 

Melting Point: 252.5-253.7 °C(lit.)

 

Boiling Point: 549.2±60.0 °C(Predicted)

 

pKa: 2.52±0.10(Predicted)

 

Solubility: Soluble in DMSO; soluble in Ethanol. Insoluble in Water.

Isomeric SMILES: C1CCC(CC1)COC2=NC(=NC(=C2N=O)N)N  

 

InChIKey: DGWXOLHKVGDQLN-UHFFFAOYSA-N  

 

InChI: InChI=1S/C11H17N5O2/c12-9-8(16-17)10(15-11(13)14-9)18-6-7-4-2-1-3-5-7/h7H,1-6H2,(H4,12,13,14,15)

 

Attribute
[CAS No.]	220036-08-8
[Formula]	C11H17N5O2
[Molecular]	251.28
[Chem Name]	6-(cyclohexylmethoxy)-5-nitrosopyrimidine-2,4-diamine
[Synonym]	NU6027
[Storage]	Inert atmosphere. Store in freezer, under -20°C
[MDL No.]	MFCD05664735
[Form]	Reddish-purple powder

Goods Tag