NSC 23766 is a Rac GTPase inhibitor, targeting Rac activation by guanine nucleotide factors (GEFs), with IC50 of ~50 μM in cell free assay. But it does not inhibit closely related targets, Cdc42 or RhoA.

 

Brand: BCM

 

Target: Apoptosis; Rho; Ras

 

Signaling Pathways: Apoptosis; Cell Cycle/Checkpoint; GPCR/G Protein; MAPK

 

Melting Point: >225°C (dec.)

 

Solubility: Soluble in DMSO (warmed with 50ºC water bath); soluble in Water (warmed with 50ºC water bath). Insoluble in Ethanol.

Isomeric SMILES: CCN(CC)CCCC(C)NC1=NC(=CC(=N1)NC2=CC3=C(C=C(N=C3C=C2)C)N)C.Cl.Cl.Cl  

 

InChIKey: CPUHORIUXPQCHW-UHFFFAOYSA-N  

 

InChI: InChI=1S/C24H35N7.3ClH/c1-6-31(7-2)12-8-9-16(3)27-24-28-18(5)14-23(30-24)29-19-10-11-22-20(15-19)21(25)13-17(4)26-22;;;/h10-11,13-16H,6-9,12H2,1-5H3,(H2,25,26)(H2,27,28,29,30);3*1H

 

Attribute
[CAS No.]	1177865-17-6
[Formula]	C24H35N7.3HCl
[Molecular]	530.96
[Chem Name]	6-N-[2-[5-(diethylamino)pentan-2-ylamino]-6-methylpyrimidin-4-yl]-2-methylquinoline-4,6-diamine;trihydrochloride
[Synonym]	NSC 23766 (hydrochloride); NSC 23766
[Storage]	Keep in dark place. Inert atmosphere. Room temperature
[MDL No.]	MFCD08703096
[Form]	White to beige powder

Goods Tag