MLN0905 is a potent PLK1 inhibitor with an IC50 of 2 nM.

 

Brand: BCM

 

Target: PLK

 

Signaling Pathways: Cell Cycle/Checkpoint

 

Boiling Point: 624.4±65.0 °C(Predicted)

 

pKa: 9.80±0.20(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Water; insoluble in Ethanol.

 

GHS: GHS07

 

Isomeric SMILES: CC1=C(C=C(C=N1)CCCN(C)C)NC2=NC=C3CC(=S)NC4=C(C3=N2)C=CC(=C4)C(F)(F)F  

 

InChIKey: CODBZFJPKJDNDT-UHFFFAOYSA-N  

 

InChI: InChI=1S/C24H25F3N6S/c1-14-19(9-15(12-28-14)5-4-8-33(2)3)31-23-29-13-16-10-21(34)30-20-11-17(24(25,26)27)6-7-18(20)22(16)32-23/h6-7,9,11-13H,4-5,8,10H2,1-3H3,(H,30,34)(H,29,31,32) 

 

Attribute
[CAS No.]	1228960-69-7
[Formula]	C24H25F3N6S
[Molecular]	486.56
[Chem Name]	2-[[5-[3-(dimethylamino)propyl]-2-methylpyridin-3-yl]amino]-9-(trifluoromethyl)-5,7-dihydropyrimido[5,4-d][1]benzazepine-6-thione
[Synonym]	MLN0905
[Storage]	Store at -20°C
[MDL No.]	MFCD22683863
[Form]	Solid Powder

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