ML141 (CID-2950007) is a potent, selective reversible non-competitive inhibitor of the Rho family GTPase cdc42 with an IC50 of 200 nM. cdc42 is more selective than GTPases in other Rho families (such as Rac1, Rab2, Rab7). ML141 is associated with increased p38 activation and may induce P38-dependent apoptosis/senescence. ML141 also protects neuroblastoma cells from metformin-induced apoptosis.

 

Brand: BCM

 

Target: cdc42

 

Melting Point: 216 °C(Solv: ethanol (64-17-5))

 

Boiling Point: 622.9±65.0 °C(Predicted)

 

Solubility: Soluble in DMSO (warmed with 50ºC water bath). Insoluble in Water; insoluble in Ethanol.

 

pKa: 10.39±0.10(Predicted)

 

GHS: GHS07

 

Isomeric SMILES: COC1=CC=C(C=C1)C2CC(=NN2C3=CC=C(C=C3)S(=O)(=O)N)C4=CC=CC=C4  

 

InChIKey: QBNZBMVRFYREHK-UHFFFAOYSA-N  

 

InChI: InChI=1S/C22H21N3O3S/c1-28-19-11-7-17(8-12-19)22-15-21(16-5-3-2-4-6-16)24-25(22)18-9-13-20(14-10-18)29(23,26)27/h2-14,22H,15H2,1H3,(H2,23,26,27)

 

Attribute
[CAS No.]	71203-35-5
[Formula]	C22H21N3O3S
[Molecular]	407.49
[Chem Name]	4-[3-(4-methoxyphenyl)-5-phenyl-3,4-dihydropyrazol-2-yl]benzenesulfonamide
[Synonym]	ML 141; ML141; ML-141; CID-2950007
[Storage]	Sealed in dry. Room Temperature
[MDL No.]	MFCD05987165
[Form]	Yellow-white solid

Goods Tag