Pleuromutilin can inhibit protein synthesis of the bacterium by binding the ribosome subunit 50S.

Pleuromutilin is a kind of broad-spectrum diterpene antibiotic produced by Pleurotus mutilus, which is the precursor of semi-synthetic derivatives of pleuromutilin. Pleurotins truncate is a family of antibiotics with good antibacterial activity, which can effectively inhibit most Gram-positive bacteria and some Gram-negative bacteria. Pleurotin truncated was first isolated and preliminarily identified by Kavanagh et al in 1951. In 1976, Knauseder et al. conducted a preliminary study on the fermentation conditions, chemical structure and biosynthetic pathway of pleuloplein truncated producing bacterium Clitoilus passeckerianus.

 

Brand: BCM

 

Melting Point: 170 ~ 171 °C

 

pKa: 12.91±0.10(Predicted)

 

Optical activity: [α]/D +30 to +40° (c=1; CH2Cl2)

 

Solubility: Soluble in DMSO; soluble in Ethanol. Insolubel in Water.

 

Attribute
[CAS No.]	125-65-5
[Formula]	C22H34O5
[Molecular]	378.50
[Chem Name]	(3aS,4R,5S,6S,8R,9R,9aR,12R)-5-Hydroxy-4,6,9,12-tetramethyl-1-oxo-6-vinyldecahydro-3a,9-propanocyclopenta[8]annulen-8-yl 2-
[Synonym]	Pleuromutilin; Drosophilin B, Mutilin 14-glycolate
[EINECS]	204-747-5
[MDL No.]	MFCD28154633
[Form]	White to beige powder
[Storage]	Keep in dark place. Inert atmosphere,Store in freezer, under -20°C

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